研究業績

Papers | Books | Reviews | Proceedings | Patents | Budgets

Papers

Corresponding Author*

      1. Akihiro Imaeda, Fumiaki Tomoike, Mayu Hayakawa, Kosuke Nakamoto, Yasuaki Kimura, Naoko Abe & Hiroshi Abe*
        N6-methyl adenosine in siRNA evades immune response without reducing RNAi activity
        Nucleosides, Nucleotides and Nucleic Acids, 1-8(2019)
      2. Zhaoma Shu, Iku Tanaka, Azumi Ota, Daichi Fushihara, Naoko Abe, Saki Kawaguchi, Kosuke Nakamoto, Fumiaki Tomoike, Seiichi Tada, Yoshihiro Ito, Yasuaki Kimura, Hiroshi Abe*
        Disulfide‐unit conjugation enables ultrafast cytosolic internalization of antisense DNA and siRNA
        Angewandte Chemie International Edition, 58, 6611-6615(2019)
      3. Yuko Shishido, Fumiaki Tomoike, Keiko Kuwata, Haruka Fujikawa, Yoshitaka Sekido, Yuko Murakami-Tonami, Tomoshi Kameda, Naoko Abe, Yasuaki Kimura, Satoshi Shuto, Hiroshi Abe*
        A Covalent Inhibitor for Glutathione S‐Transferase Pi (GSTP1‐1) in Human Cells
        ChemBioChem, 20, 900-905(2019).
      4. Kazumitsu Onizuka, Takuya Miyashita, Tomoko Chikuni, Mamiko Ozawa, Hiroshi Abe, Fumi Nagatsugi*
        Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation
        Nucleic Acids Research, 46, 8710-8719(2018).
      5. Lars Bräutigam, Jie Zhang, Kristian Dreij, Linda Spahiu, Arne Holmgren, Hiroshi Abe, Kenneth D. Tew, Danyelle M. Townsend, Michael J. Kelner, Ralf Morgenstern*,Katarina Johansson
        MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation
        Redox Biology, 17, 171-179(2018).
      6. Yuko Shishido, Fumiaki Tomoike, Yasuaki Kimura, Keiko Kuwata, Takato Yano, Kenji Fukui, Haruka Fujikawa, Yoshitaka Sekido, Yuko Murakami-Tonami, Tomoshi Kameda, Satoshi Shuto, Hiroshi Abe*
        A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1)
        Chemical Communications, 53, 11138-11141(2017).
      7. John C. Walton*, Ryutaro Kanada, Takeaki Iwamoto, Satoshi Shuto, Hiroshi Abe*
        Tethered 1,2-Si-Group Migrations in Radical-Mediated Ring Enlargements of Cyclic Alkoxysilanes: An EPR Spectroscopic and Computational Investigation
        Journal of Organic Chemistry, 82(13), 6886-6894(2017)
      8. Hideto Maruyama, Ryota Oikawa, Mayu Hayakawa, Shono Takamori, Yasuaki Kimura, Naoko Abe, Genichiro Tsuji, Akira Matsuda, Satoshi Shuto, Yoshihiro Ito, Hiroshi Abe*
        Chemical ligation of oligonucleotides using an electrophilic phosphorothioester
        Nucleic Acids Research, 45(12), 7042-7048 (2017).
      9. Baiju G. Nair, Yue Zhou, Kyoji Hagiwara, Masashi Ueki, Takashi Isoshima, Hiroshi Abe, Yoshihiro Ito*
        Enhancement of synergistic gene silencing by RNA interference using branched “3-in-1” trimer siRNA
        Journal of Materials Chemistry B, 5, 4044-4051 (2017).
      10. Kazumitsu Onizuka, Tomoko Chikuni, Takuya Amemiya, Takuya Miyashita, Kyoko Onizuka, Hiroshi Abe, Fumi Nagatsugi*
        Pseudorotaxane formation via the slippage process with chemically cyclized oligonucleotides
        Nucleic Acids Research, 45 (9), 5036-5047 (2017).
      11. Hayato Fukuda, Ryuta Muromoto, Yuuki Takakura, Kohei Ishimura, Ryutaro Kanada, Daichi Fushihara, Makoto Tanabe, Kotaro Matsubara, Toru Hirao, Koki Hirashima, Hiroshi Abe, Mitsuhiro Arisawa, Tadashi Matsuda, Satoshi Shuto*
        Design and Synthesis of Cyclopropane Congeners of Resolvin E2, an Endogenous Proresolving Lipid Mediator, as Its Stable Equivalents
        Organic Letters, 18, 6224-6227 (2016).
      12. Marcus Cebula, Ilke Simsek Turan, Birgitta Sjödin, Madhuranayaki Thulasingam, Joseph Brock, Volodymyr Chmyrov, Jerker Widengren, Hiroshi Abe, Bengt Mannervik, Jesper Haeggström, Agnes Rinaldo-Matthis, Engin Akkaya, Ralf Morgenstern*
        Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase
        Scientific Reports, 6, 38316 (2016) .
      13. Marike van Gisbergen, Marcus Cebula, Jie Zhang, Astrid Ottosson-Wadlund, Ludwig Dubois, Philippe Lambin, Kenneth D. Tew, Danyelle Townsend, Guido Haenen, Marie-José Drittij-Reijnders, Hisao Saneyoshi, Mika Araki, Yuko Shishido, Yoshihiro Ito, Elias Arnér, Hiroshi Abe, Ralf Morgenstern, Katarina Johansson*
        Chemical reactivity window determines prodrug efficiency towards glutathione transferase overexpressing cancer cells
        Molecular Pharmaceutics, 13(6), 2010-2025 (2016).
      14. Hiroki Kumamoto*, Misato Fukano, Tomohiko Nakano, Keito Iwagami, Chiaki Takeyama, Satoru Kohgo, Shuhei Imoto, Masayuki Amano, Nobuyo Kuwata-Higashi, Manabu Aoki, Hiroshi Abe, Hiroaki Mitsuya, Kiyoshi Fukuhara, Kazuhiro Haraguchi
        Diastereoselective Synthesis of 6″‑(Z)- and (E)‑Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers
        Journal of Organic Chemistry, 81, 2827-2836 (2016).
      15. Naoko Abe, Ken Matsumoto, Mizuki Nishihara, Yukiko Nakano, Aya Shibata, Hideto Maruyama, Satoshi Shuto, Akira Matsuda, Minoru Yoshida, Yoshihiro Ito, Hiroshi Abe*
        Rolling Circle Translation of Circular RNA in Living Human Cells
        Scientific Reports, 5, 16435 (2015).
      16. Siyoong Seo, Kazumitsu Onizuka, Chieko Nishioka, Eiki Takahashi, Satoshi Tsuneda, Hiroshi Abe, Yoshihiro Ito
        Phosphorylated 5-ethynyl-2′-deoxyuridine for advanced DNA labeling
        Organic & Biomolecular Chemistry, 13(15), 4589-4595 (2015).
      17. Keisuke Yotsuji, Naoyuki Hoshiya, Takaaki Kobayashi, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa, Satoshi Shuto
        Nickel-Catalyzed Suzuki-Miyaura Coupling of a Tertiary Iodocyclopropane with Wide Boronic Acid Substrate Scope: Coupling Reaction Outcome Depends on Radical Species Stability
        Advanced Synthesis & Catalysis, 357(5), 1022-1028 (2015).
      18. Hisashi Shimada, Kazuhiro Haraguchi*, Kumi Hotta, Tomoko Miyaike, Yasuyuki Kitagawa, Hiromichi Tanaka, Ryutaro Kaneda, Hiroshi Abe, Satoshi Shuto, Kyoko Mori, Youki Ueda, Nobuyuki Kato, Robert Snoeck, Graciela Andrei, an Balzarini
        Synthesis of 3’,4’-difluoro-3’-deoxyribonucleosides and its evaluation of the biological activities: Discovery of a novel type of anti-HCV agent 3’,4’-difluorocordycepin
        Bioorganic & Medicinal Chemistry, 22(21), 6174-6182 (2014).
      19. Takaaki Kobayashi, Akihiro Suemasa, Arisa Igawa, Soichiro Ide, Hayato Fukuda, Hiroshi Abe, Mitsuhiro Arisawa, Masabumi Minami, Satoshi Shuto*
        Conformationally Restricted GABA with Bicyclo[3.1.0]hexane Backbone as the First Highly Selective BGT‑1 Inhibitor
        ACS Medicinal Chemistry Letters, 5(8), 889-893 (2014).
      20. Kazumitsu Onizuka*, Fumi Nagatsugi, Yoshihiro Ito, Hiroshi Abe*
        Automatic Pseudorotaxane Formation Targeting on Nucleic Acids Using a Pair of Reactive Oligodeox-ynucleotides
        Journal of the American Chemical Society,136 (20), 7201–7204 (2014).
      21. Hisao Saneyoshi, Tatsuya Ochikubo, Takushi Mashimo, Ken Hatano, Yoshihiro Ito*, Hiroshi Abe*
        Triphenylphosphinecarboxamide: An Effective Reagent for the Reduction of Azides and its Application to Nucleic Acid Detection
        Organic Letters 16 (1), 30-33 (2014).
      22. Hideto Maruyama, Yuko Nakashima, Satoshi Shuto, Akira Matsuda, Yoshihiro Ito*, Hiroshi Abe*
        Intracellular buildup reaction of active siRNA species from short RNA fragments
        Chemical Communications 50, 1284-1287 (2014).
      23. Baiju G Nair, Yukiko Nakano, Yoshihiro Ito*, Hiroshi Abe*
        Transmembrane molecular transport through nanopores formed by protein nanotubes
        Chemical Communications 50, 602-604 (2014).
      24. Yutaka Kubota, Yuri Kaneda, Kazuhiro Haraguchi,*, Mirei Mizuno, Hiroshi Abe, Satoshi Shuto, Takayuki Hamasaki, Masanori Baba, Hiromichi Tanaka
        Synthesis of novel 40-C-methyl-10,30-dioxolane pyrimidine nucleosides and evaluation of its anti-HIV-1 activity
        Tetrahedron 69, 10884-10892 (2013)
      25. Aya Shibata, Yukiko Nakano, Mika Ito, Mika Araki, Jie Zhang, Yasuhiko Yoshida, Satoshi Shuto, Bengt Mannervik, Ralf Mogenstern, Yoshihiro Ito*, Hiroshi Abe*
        Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions
        Analyst 138, 7326-7330 (2013).
      26. Hisao Saneyoshia, Naohiko Shimada, Atsushi Maruyama, Yoshihiro Ito*, Hiroshi Abe*
        Polycation-assisted DNA detection by reduction triggered fluorescence amplification probe
        Bioorganic & Medicinal Chemistry Letters 23(24), 6851-6853 (2013).
      27. Jeonghwa Kang, Seiichi Tada, Makoto Sakuragi, Hiroshi Abe, Reiko Ito, Junko Ishikawa, Shino Kurata, Takashi Kitajima, Tae Il Son, Toshiro Aigaki, and Yoshihiro Ito*
        An epidermal growth factor derivative with binding affinity for hydroxyapatite and titanium surfaces
        Biomaterials, 34, 9747-9753 (2013).
      28. Hisao Saneyoshi Yoshihiro Ito*, Hiroshi Abe*
        Long-lived luminogenic probe for detection of RNA in a crude solution of living bacterial cells
        Journal of the American Chemical Society, 135 (37), 13632–13635 (2013).
      29. Aya Shibata, Takanori Uzawa, Yuko Nakashima, Mika Ito, Yukiko Nakano, Satoshi Shuto, Yoshihiro Ito*, Hirosi Abe*
        Very rapid DNA templated reaction for efficient signal amplification and its steady-state kinetic analysis of the turnover cycle
        Journal of the American Chemical Society, 135 (38), 14172−14178 (2013).
      30. Naoko Abe, Michio Hiroshima, Hideto Maruyama, Yuko Nakashima, Yukiko Nakano, Akira Matsuda, Yasushi Sako, Yoshihiro Ito*, Hiroshi Abe*
        Rolling circle amplification in a prokaryotic translation system using small circular RNA
        Angewandte Chemie International Edition, 52(27), 7004-7008 (2013)
      31. Binata Joddar*, Aydin Albayrak, Jeonghwa Kang, Mizuki Nishihara, Hiroshi Abe, Yoshihiro Ito*
        Sustained delivery of siRNA from dopamine-coated stainless steel surfaces
        Acta Biomaterialia 9, 6753-6761 (2013).
      32. Hisao Saneyoshi, Takushi Mashimo, Ken Hatano, Yoshihiro Ito*, Hiroshi Abe*
        Synthesis of a nucleoside phosphorodithioate analogue responsive to microenvironmental changes through chiral induction
        Tetrahedron Letters 54, 1080–1083 (2013).
      33. Pallavi Ananda Kadengodlu, Toshiro Aigaki, Hiroshi Abe*, Yoshihiro Ito*
        Cationic cholesterol-modified gelatin as an in vitro siRNA delivery vehicle
        Molecular Biosystems 9, 965-968 (2013).
      34. Mitsuhiro Arisawa, Yuki Fujii, Hiroshige Kato, Hayato Fukuda, Takashi Matsumoto, Mika Ito, Hiroshi Abe, Yoshihiro Ito, and Satoshi Shuto.
        One-Pot Ring-Closing Metathesis/1,3-Dipolar Cycloaddition through Assisted Tandem Ruthenium Catalysis: Synthesis of a Dye with Isoindolo[2,1-a]quinoline Structure
        Angewandte Chemie International Edition 52 (3) 1003-1007 (2013).
      35. Aya Shibata, Yoshihiro Ito, Hiroshi Abe
        RNA-templated molecule release induced protein expression in bacterial cells
        Chemical Communications, 49, 270-272 (2013).
      36. Mingzhe Liu, Seiichi Tada, Mika Ito, Hiroshi Abe, Yoshihiro Ito
        In vitro selection of a photo-responsive peptide aptamer by ribosome display
        Chemical Communications, 48, 11871-11873 (2012).
      37. Hiroki Kumamoto, Sachiko Kawahigashi, Hiromi Wakabayashi, Tomohiko Nakano, Tomoko Miyaike, Yasuyuki Kitagawa, Hiroshi Abe, Mika Ito, Kazuhiro Haraguchi, Jan Balzarini,c Masanori Babad, Hiromichi Tanaka
        Tuning efficiency of the 4-exo-trig cyclization by the electronic effect: ring closure of 3,3-difluoro-4-pentenyl carbon radicals and synthesis of a gem-difluorocyclobutane nucleosidew
        Chemical Communications, 48, 10993-10995 (2012)
      38. Yasutsugu Tamura, Kazuhiro Furukawa, Rei Yoshimoto, Yuto Kawai, Minoru Yoshida, Satoshi Tsuneda, Yoshihiro Ito, Hiroshi Abe
        Detection of Pre-mRNA Splicing in vitro by an RNA-Templated Fluorogenic Reaction
        Bioorganic Medicinal Chemistry Letters, 22(23) 7248-7251 (2012)
      39. Mitsuhiro Arisawa, Yayoi Kasay, Tohru Obata, Takuma Sasaki, Tomonori Nakamura, Takuya Araki, Koujirou yamamoto, Akito Sasaki, Akihito Yamano, Mika Ito, Hiroshi Abe, Yoshihiro Ito, and Satoshi Shuto
        Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without Cox inhibitory activity
        Journal of Medicinal Chemistry, 55 (18) 8152-8163 (2012)
      40. Pallavi Ananda Kadengodlu, Takehisa Hebishima, Shin-nosuke Takeshima, Mika Ito, Mingzhe Liu, Hiroshi Abe, Yoko Aida, Toshiro Aigaki, and Yoshihiro Ito
        Positively but not negatively charged cholesterol–recombinant human gelatins foster the cellular uptake of proteins and murine immune reactions
        International Journal of Nanomedicine, 7:5437-5450 (2012).
      41. Jeonghwa Kang, Makoto Sakuragi, Aya Shibata, Hiroshi Abe, Takashi Kitajima, Seiichi Tada, Masayoshi Mizutani, Hitoshi Ohmori, Hiroto Ayame, Tae Il Son, Toshiro Aigaki, and Yoshihiro Ito
        Immobilization of epidermal growth factor on titanium and stainless steel surfaces via dopamine treatment
        Materials Science and Engineering: C, 32 (8) 2552-2561 (2012)
      42. Mika Ito, Aya Shibata, Jie Zhang, Michio Hiroshima, Yasushi Sako, Yukiko Nakano, Kyoko Kojima-Aikawa, Bengt Mannervik, Satoshi Shuto, Yoshihiro Ito, Ralf Morgenstern*, Hiroshi Abe*
        Universal Caging Group for In Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes
        ChemBioChem, 13 (10) 1428-1432, (2012)
      43. Hiroshi Abe,* Naoko Abe, Aya Shibata, Keiji Ito, Yoshiyuki Tanaka, Mika Ito, Hisao Saneyoshi, Satoshi Shuto, and Yoshihiro Ito*
        Structure Formation and Catalytic Activity of DNA in Organic Solvents
        Angewandte Chemie International Edition, 51 (26) 6475-6479, (2012)
      44. Naoko Abe, Hiroshi Abe*, Yoshihiro Ito
        Synthesis of Dumbbell-Shaped Cyclic RNAs for RNA Interference.
        Current Protocol Nucleic Acid Chemistry, 48:16.4.1-16.4.11 (2012)
      45. Aya Shibata, Hiroshi Abe*, and Yoshihiro Ito
        Oligonucleotide-Templated Reactions for Sensing Nucleic Acids
        Molecules, 17(3), 2446-2463 (2012)
      46. Kazuhiro Furukawa, Hiroshi Abe*, Yasutsugu Tamura, Rei Yoshimoto, Minoru Yoshida, Satoshi Tsuneda and Yoshihiro Ito*
        Fluorescent Detection of Intron Lariat RNAs with Reduction-Triggered Fluorescence Probes
        Angewandte Chemie International Edition, 50(50) 12020-12023, (2011).
      47. Kazuhiro Haraguchi, Hisashi Shimada, Keigo Kimura, Genta Akutsu, Hiromichi Tanaka, Hiroshi Abe, Takayuki Hamasaki, Masanori Baba, Elizabeth A. Gullen, Ginger E. Dutschman, Yung-Chi Cheng, and Jan Balzarini
        Synthesis of 4′-Ethynyl-2′-deoxy-4′-thioribonucleosides and Discovery of a Highly Potent and Less Toxic NRTI
        ACS Medicinal Chemistry Letters, 2(9), 692-697, (2011).
      48. Jie Zhang, Aya Shibata, Mika Ito, Satoshi Shuto, Yoshihiro Ito, Bengt Mannervik, Hiroshi Abe*, Ralf Morgenstern*
        Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy
        Journal of the American Chemical Society, 133(35), 14109-14119, (2011).
      49. Naoko Abe, Hiroshi Abe*, Chisato Nagai, Mitsuru Harada, Hiroto Hatakeyama, Hideyoshi Harashima, Takahito Ohshiro, Mizuki Nishihara, KazuhiroFurukawa, Mizuo Maeda, Satoshi Tsuneda, and Yoshihiro Ito*
        Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference
        Bioconjugate Chemistry, 22(10), 2082-2092, (2011).
      50. Katarina Johansson, Mika Ito, Carolien M. S. Schophuizen, Sherin Mathew T, Vanina D. Heuser, Jie Zhang, Miyuki Shimoji, Marie Vahter, Wee Han Ang, Paul J. Dyson, Aya Shibata, Satoshi Shuto, Yoshihiro, Ito, Hiroshi Abe, Ralf Morgenstern*
        Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance
        Molecular Pharmaceutics., 8(5), 1698-1708, (2011).
      51. Mingzhe Liu, Muye Xu, Xian Jun Loh, Hiroshi Abe, Takeshi Tsumuraya, Ikuo Fujii, Jun Li, Tae Il Son, and Yoshihiro Ito*
        PEGylated antibody in organic media
        Journal of Bioscience and Bioengineering, 111(5), 564-568 (2011).
      52. Yuko Nakashima, Hiroshi Abe*, Naoko Abe, Kyoko Aikawa, Yoshihiro Ito*
        Branched RNA Nanostructures for RNA Interference
        Chemical Communications, 47, 8367-8369 (2011).
      53. Mitsuhiro Arisawa*, Yayoi Kasaya, Tohru Obata, Takuma Sasaki, Mika Ito, Hiroshi Abe, Yoshihiro Ito, Akihito Yamano, Satoshi Shuto*
        Design and Synthesis of Conformationally Restricted Indomethacin Analogues. Identification of Indomethacin Analogues that Enhance Doxorubicin Cytotoxicity in Multidrug Resistant Cells without Cyclooxygenase Inhibitory Activity
        ACS Medicinal Chemistry Letter, 2, 353-357 (2011).
      54. Naoko Abe, Hiroshi Abe*, Takahito Ohshiro, Yuko Nakashima, Mizuo Maeda, Yoshihiro Ito*
        Synthesis and Characterization of Small Circular Double-Stranded RNAs
        Chemical Communication 47, 2125-2127 (2011).
      55. Yasuyuki Hirama, Hiroshi Abe, Noriaki Minakawa, Akira Matsuda
        Synthesis and properties of a novel nucleoside derivative possessing a 2,3,5,6-tetraazabenzo[cd]azulene skeleton.
        Tetrahedron 66, 8402-8406 (2010).
      56. Kazuhiro Furukawa, Hiroshi Abe*, Satoshi Tsuneda, Yoshihiro Ito*
        Photoactivatable fluorescein derivatives with azidomethyl caging groups for tracing oligonucleotides in living human cells.
        Organic Biomolecular Chemistry 8, 2309-2311 (2010).
      57. Mingzhe Liu, Hiroshi Jinmei, Hiroshi Abe, Yoshihiro Ito*
        In vitro selection of a photoresponsive RNA aptamer to hemin.
        Bioorganic & Medicinal Chemistry Letters 20, 2964–2967 (2010).
      58. Tetsuya Mochizuki, Akihiko Tanimura, Akihiro Nezu, Mika Ito, Hiroshi Abe, Yoshihiro Ito, Mitsuhiro Arisawa a, Satoshi Shuto*
        Design and synthesis of indole derivatives of adenophostin A. A entry into subtype-selective IP3 receptor ligands.
        Tetrahedron Letter 51, 977-979 (2010).
      59. Takaaki Kobayashi, Mizuki Watanabe, Akira Yoshida, Shizuo Yamada, Mika Ito, Hiroshi Abe, Yoshihiro Ito, Mituhiro Arisawa, Satoshi Shuto*
        Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.
        Biorganic Medicinal Chemistry 18, 1076-1082 (2010).
      60. Aya Shibata, Hiroshi Abe*, Mika Ito, Yuko Kondo, Shigeru Shimizu, Kyoko Aikawa, Yoshihiro Ito*
        DNA templated nucleophilic aromatic substitution reactions for fluorogenic sensing of oligonucleotides
        Chemical Communications, 43, 6586-6588 (2009).
      61. Aya Shibata, Hiroshi Abe*, Kazuhiro Furukawa, Satoshi Tsuneda, Yoshihiro Ito*
        Reduction-triggered fluorescence probe for peptide-templated reactions
        Chemical Pharmaceutical Bulletin, 57, 1223-1226 (2009).
      62. Johan Ålander, Katarina Johansson, Vanina Dahlström Heuser, Henny Farebo, Julia Järvliden, Hiroshi Abe, Aya Shibata, Mika Ito, Yoshihiro Ito, Ralf Morgenstern*
        Characterisation of a New Fluorogenic Substrate for Microsomal Glutathione Transferase 1
        Analytical Biochemistry, 390, 52-56 (2009).
      63. Norihiko Hayazawa*, Kentaro Furusawa, Atsushi Taguchi, Satoshi Kawata, Hiroshi Abe
        Tip-enhanced two-photon excited fluorescence microscopy with a silicon
        Applied Physics Letters 94, 193112 (2009).
      64. Kazuhiro Furukawa, Hiroshi Abe*, Kayoko Hibino, Yasushi Sako, Satoshi Tsuneda, Yoshihiro Ito*
        Reduction-triggered Fluorescent Amplification Probe for Detection of endogenous RNAs in Living Human Cells
        Bioconjugate Chemistry, 20, 1026–1036 (2009).
      65. Mingzhe Liu, Takuma Kagahara, Hiroshi Abe, and Yoshihiro Ito*
        In Vitro Selection of Hemin-Binding catalytic RNA
        Bioorganic Medicinal Chemistry Letters 19, 1484-1487 (2009) .
      66. Kazuhiro Furukawa, Hiroshi Abe*, Jin Wang, Miwako Uda, Satoshi Tsuneda, Yoshihiro Ito*
        Reduction-triggered red fluorescent probes for dual-color detection of oligonucleotide sequences
        Organic Biomolecular Chemistry 7, 671-677 (2009).
      67. Mingzhe Liu, Takuma Kagahara, Hiroshi Abe, and Yoshihiro Ito*
        Direct In Vitro Selection of Hemin-Binding DNA Aptamer with Peroxidase Activity
        Bulletin of the Chemical Society of Japan, 82, 99-104 (2009).
      68. Kazuhiro Frukawa, Hiroshi Abe*, Naoko Abe, Mitsuru Harada, Satoshi Tsuneda, Yoshihiro Ito
        Fluorescence generation from tandem repeats of a malachite green RNA aptamer using rolling circle transcription.
        Bioorganic Medicinal Chemistry Letters 18, 4562-4565 (2008).
      69. Hiroshi Abe*, Jin Wang, Kazuhiro Furukawa, Kazuma Oki, Miwako Uda, Satoshi Tsuneda, Yoshihiro Ito*
        A reduction-triggered fluorescence probe for sensing nucleic acids
        Bioconjugate Chemistry, 19, 1219-1226 (2008).
      70. Adam P Silverman, Hiroshi Abe, Eric T Kool*
        Quenched autoligation probes.
        Methods in Molecular Biology, 429, 161-170 (2008).
      71. Aya Shibata, Kazuhiro Frukawa, Hiroshi Abe*, Satsohi Tsuneda, Yoshihiro Ito*
        Rhodamine-based fluorogenic probe for imaging biological thiol
        Bioorganic Medicinal Chemistry Letters 18, 2246-2249 (2008).
      72. Satoshi Shuto*, Satoshi Ichikawa, Hiroshi Abe, Akira Matsuda*
        Stereoselective glycosylation based on the conformational restriction of pyranoses.
        Yuki Gosei Kagaku Kyokaishi 66, 50-60 (2008).
      73. Hiroki Kumamoto*, Nonoko Takahashi, Tomomoi Shimamura, Hiromichi Tanaka, Kazuo T. Nakamura, Takayuki Hamasaki, Masanori Baba, Hiroshi Abe, MasahikoYano, Nobuyuki Kato.
        Synthesis of (+/-)-9-[c-4, t-5-bis(hydroxymethyl)cyclopent-2-en-r-1-yl]-9H-adenine (BCA) derivatives branched at the 4′-position based on intramolecular SH2′ cyclization.
        Tetrahedron, 64, 1494-1505 (2008).
      74. Mingze Liu, Hiroshi Jinmei, Hiroshi Abe*, Yoshihiro Ito*
        Chemical aminoacylation of RNA by an intermolecular adenosine transfer reaction
        Chemistry Letters. 37, 102-103 (2008).
      75. Hiroshi Abe*, Yuko Kondo, Hiroshi Jinmei, Naoko Abe, Kazuhiro Furukawa, Atsushi Uchiyama, Satoshi Tsuneda, Kyoko Aikawa, Isamu Matsumoto, Yoshihiro Ito*
        Rapid DNA chemical ligation for amplification of RNA and DNA signal
        Bioconjugate Chemistry, 19, 327-333 (2008).
      76. Naoko Abe, Hiroshi Abe*, Yoshiiro Ito*
        Dumbbell-shaped nanocircular RNAs for RNA interference.
        Journal of the American Chemical Society, 129, 15108-15109 (2007).
      77. Tetsuya Mochizuki, Yoshihiko Kondo, Hiroshi Abe, Stephen C. Tovey, Skarlatos G. Dedos, Colin W. Taylor, Michael Paul, Barry V. L. Potter, Akira Matsuda, Satoshi Shuto*
        Synthesis of adenophostin A analogues conjugating an aromatic group at the 5′-position as potent IP3 receptor ligands.
        Journal of Medicinal Chemistry, 49, 5750-5758 (2006).
      78. Tetsuya Mochizuki, Yoshihiko Kondo, Hiroshi Abe, Collin W. Taylor, Barry V. L. Potter, Akira Matsuda, Satoshi Shuto*
        Design and synthesis of 5′-deoxy-5′-phenyladenophostin A, a highly potent IP3 receptor ligand.
        Organic Letters, 8, 1455-1458 (2006).
      79. Masaru Terauchi, Hiroshi Abe, Stephen C. Tovey, Skarlatos G. Dedos, Colin W. Taylor, Michael Paul, Melanie Trusselle, Barry V. L. Potter, Akira Matsuda, Satoshi Shuto*
        A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. synthesis of alpha -C-glucoside trisphosphates based on the conformational restriction strategy.
        Journal of Medicinal Chemistry, 49, 1900-1909 (2006).
      80. Hiroshi Abe, Eric T. Kool*
        Flow cytometric detection of specific RNAs in native human cells with quenched auto ligating FRET probes
        Proceedings of the National Academy of Sciences of the United States of America, 103, 263-268 (2006).
      81. Masaru Terauchi, Yumi Yahiro, Hiroshi Abe, Satoshi Ichikawa, Stephen C. Tovey, Skarlatos G. Dedos, Colin W. Taylor, Barry. V. L. Potter, Akira Matsuda*, Satoshi Shuto*
        Synthesis of 4,8-anhydro-D-glycero-D-ido-nonanitol 1,6,7-trisphosphate as a novel IP3 receptor ligand using a stereoselective radical cyclization reaction based on a conformational restriction strategy.
        Tetrahedron 61, 3697-3707 (2005).
      82. Hiroshi Abe, Eric T. Kool*
        Destabilizing Universal Linkers for Signal Amplification in Self-Ligating Probes for RNA.
        Journal of the American Chemical Society, 126, (43), 13980-13986 (2004).
      83. Yuji Kazuta, Hiroshi Abe, Akira Matsuda, Satoshi Shuto*
        Highly Stereoselective Grignard Addition to Cis-Substituted C-Cyclopropylaldonitrones. The Bisected s-Trans Transition State Can Be Stabilized Effectively by the Lewis Acid-Coordination
        Journal of Organic Chemistry, 69, 9143-9150 (2004).
      84. Masaru Terauchi, Hiroshi Abe, Aakira Matsuda*, Satoshi Shuto*
        An efficient synthesis of beta-C-glycosides based on the conformational restriction strategy: Lewis acid promoted silane reduction of the anomeric position with complete stereoselectivity.
        Organic Letters, 6, (21), 3751-3754, (2004).
      85. Yuji Kazuta, Hiroshi Abe, Tamotsu Yamamoto, Akira Matsuda, Satoshi Shuto*
        The unusual 1,4-chelation-controlled nucleophilic addition to aldehydes with high stereoselectivity. A systematic study of stereoselectivity in the addition reaction of carbon nucleophiles to cis-substituted cyclopropanecarbaldehydes.
        Tetrahedron, 60, (31), 6689-6703 (2004).
      86. Sinsuke Sando, Hiroshi Abe, Eric T. Kool*
        Quenched auto-Ligating DNAs: Multicolor identification of Nucleic Acids at Single Nucleotide Resolution.
        Journal of the American Chemical Society, 126, (4), 1081-1087 (2004).
      87. Satoshi Shuto*, Masaru Terauchi, YumiYahiro, Hiroshi Abe, Satoshi Ichikawa, Akira Matsuda*
        Stereoselective synthesis of a- and b-C-glucosides via radical cyclization with an allylsilyl tether. Control of the stereoselectivity by changing the conformation of the pyranose ring.
        Tetrahedron Lett.45, 6819 (2004).
      88. Kazuya Yamaguchi, Yuji Kazuta, Hiroshi Abe, Akira Matsuda, Satoshi Shuto*
        Construction of a cis-Cyclopropane via Reductive Radical Decarboxylation. Enantioselective Synthesis of cis- and trans-1-Arylpiperazyl-2-phenylcyclopropanes Designed as Antidopaminergic Agents.
        Journal of Organic Chemistry, 68, (24), 9255-9262 (2003).
      89. Hiroshi Abe, Masaru Terauchi, Akira Matsuda, Satoshi Shuto*
        A Study on the Conformation-Anomeric Effect-Stereoselectivity Relationship in Anomeric Radical Reactions, Using Conformationally Restricted Glucose Derivatives as Substrates.
        Journal of Organic Chemistry, 68, (19), 7439-7447 (2003).
      90. Yuji Kazuta, Hiroshi Abe, Tamotsu Yamamoto, Akira Matsuda*, Satoshi Shuto*
        A systematic study of the hydride reduction of cyclopropyl ketones with structurally simplified substrates. Highly stereoselective reductions of trans-substituted cyclopropyl ketones via the bisected s-cis conformation.
        Journal of Organic Chemistry, 68, (9), 3511-3521 (2003).
      91. Satoru Tamura, Hiroshi Abe, Akira Matsuda*, Satoshi Shuto*
        Control of alpha/beta stereoselectivity in Lewis acid promoted C-glycosidations using a controlling anomeric effect based on the conformational restriction strategy.
        Angewandte Chemie International Edition, 42, (9), 1021-1023 (2003).
      92. Satoshi Shuto, Maki Kanazaki, Isamu Sugimoto, Satoshi Ichikawa, Yuki Nagasawa, Yoshihito Ueno, Hiroshi Abe, Noriaki Minakawa, Makoto Sukeda, Tetsuya Kodama, Makoto Nomura, Akira Matsuda*
        Development of new radical reactions with a vinylsilyl group and their application to the synthesis of branched-chain sugar nucleosides.
        Recent Advances in Nucleosides, 21-55 (2002).
      93. Kenji Kuwayama, Seiji Miyauchi, Ryoko Tateoka, Hiroshi Abe, Naoki Kamo*
        Fluorescein uptake by a monocarboxylic acid transporter in human intestinal Caco-2 cells.
        Biochemical pharmacology, 63, (1), 81-88 (2002).
      94. Hiroshi Abe, Satoshi Shuto*, Akira Matsuda*
        Highly alpha- and beta-Selective Radical C-Glycosylation Reactions Using Controlling Anomeric Effect Based on the Conformational Restriction Strategy. A Study on the Conformation-Anomeric Effect- Stereoselectivity Relationship in Anomeric Radical Reactions.
        Journal of the American Chemical Society, 123, (48), 11870-11882 (2001).
      95. Hiroshi Abe, Satoshi Shuto*, Satoru Tamura, Akira Matsuda*
        An efficient method for preparing fully O-silylated pyranoses conformationally restricted in the unusual 1C4-form.
        Tetrahedron Letters, 42, 6159-6161 (2001).
      96. Satoshi Shuto*, Masaya Fukuoka, Hiroshi Abe, Akira Matsuda*
        Intracellular Ca2+-mobilizing adenine nucleotides. Synthesis and biological activity of cyclic ADP-carbocyclic-ribose and C-glycosidic analog of adenophostin A.
        Nucleosides, Nucleotides & Nucleic Acids, 20, (4-7), 461-470 (2001).
      97. Ryoko Tateoka, Hiroshi Abe, Seiji Miyauchi, Satoshi Shuto, Akira Matsuda, Michiya Kobayashi, Katsumi Miyazaki, Naoki Kamo*
        Significance of Substrate Hydrophobicity for Recognition by an Oligopeptide Transporter (PEPT1).
        Bioconjugate Chemistry, 12, (4), 485-492 (2001).
      98. Yuji Kazuta, Satoshi Shuto*, Hiroshi Abe, Akira Matsuda*
        The bisected s-trans conformation-controlled highly stereoselective addition of Grignard reagents to C-cyclopropylaldonitrone. An efficient synthesis of 1-phenyl-2-[(S)-1-aminoalkyl]-N,N-diethylcyclopropanecarboxamides, a new class of potent NMDA receptor antagonists.
        Journal of the Chemical Society, Perkin Transactions 1, (6), 599-604 (2001).
        Organic Biomolecular Chemistry, 1, (9), 1634 (2003).
      99. Takashi Naka, Noriaki Minakawa, Hiroshi Abe, Daisuke Kaga, Akira Matsuda*
        The Stereoselective Synthesis of 4′-beta-Thioribonucleosides via the Pummerer Reaction.
        Journal of the American Chemical Society, 122, (30), 7233-7243 (2000).
      100. Satoshi Shuto, Masaru Terauchi, Yumi Yahiro, Hiroshi Abe, Satoshi Ichikawa, Akira Matsuda*
        Stereoselective synthesis of alpha- and beta-C-glucosides via radical cyclization with an allylsilyl tether. Control of the stereoselectivity by changing the conformation of the pyranose ring.
        Tetrahedron Lett., 41, (21), 4151-4155 (2000).
      101. Hiroshi Abe, Satoshi Shuto, Akira Matsuda
        Synthesis of the C-Glycosidic Analogue of Adenophostin A and Its Uracil Congener as Potential IP3 Receptor Ligands. Stereoselective Construction of the C-Glycosidic Structure by a Temporary Silicon-Tethered Radical Coupling Reaction.
        Journal of Organic Chemistry, 65, (14), 4315-4325 (2000).
      102. Satoshi Shuto*, Isamu Sugimoto, Hiroshi Abe, Akira Matsuda*
        Mechanistic Study of the Ring-Enlargement Reaction of (3-Oxa-2-silacyclopentyl)methyl Radicals into 4-Oxa-3-silacyclohexyl Radicals. Evidence for a Pentavalent Silicon-Bridging Radical Transition State in 1,2-Rearrangement Reactions of beta-Silyl Radicals.
        Journal of the American Chemical Society, 122, (7), 1343-1351 (2000).
      103. Hiroshi Abe, Satoshi Shuto, Akira Matsuda*
        Nucleosides and nucleotides. 194. Synthesis of the C-glycosidic analog of adenophostin A, a potent IP3 receptor agonist, using a temporary silicon-tethered radical coupling reaction as the key step.
        Tetrahedron Letters., 41, (14), 2391-2394 (2000).
      104. Hiroshi Abe, Momoko Satoh, Seiji Miyauchi, Satoshi Shuto, Akira Matsuda, Naoki Kamo*
        Conjugation of Dipeptide to Fluorescent Dyes Enhances Its Affinity for a Dipeptide Transporter (PEPT1) in Human Intestinal Caco-2 Cells.
        Bioconjugate Chemistry, 10, (1), 24-31 (1999).
      105. Shun-ichi Hashimoto*, Hiroki Sakamoto, Takeshi Honda, Hiroshi Abe, Sei-ichi Nakamura, Shiro Ikegami
        Armed-disarmed” glycosidation strategy based on glycosyl donors and acceptors carrying phosphoroamidate as a leaving group: a convergent synthesis of globotriaosylceramide.
        Tetrahedron Letters., 38, (52), 8969-8972 (1997).

Books

      1.  阿部洋, 木村康明, Shu Zhaoma
        オリゴ核酸を10分で細胞質内へ送達! -核酸医薬実用化への新たな一歩
        化学, 化学同人, Vol. 74, No.8,  p 34-37 (2019)
      2. 阿部洋、木村康明
        細胞内化学反応を利用したRNA干渉法の副作用回避
        PHARM STAGE p.58-61, Vol.18, No.7, 技術情報協会 (2018)
      3. 木村康明、阿部洋
        機能性核酸合成を指向した化学的核酸連結反応
        「中分子医薬に資するペプチド・核酸・糖鎖の合成技術」
        シーエムシー出版、p. 171-180 (2018)
      4. 阿部洋、木村康明
        「RNA干渉医薬の実現に向けた新手法の開発」
        Biophilia, Vol. 6, No. 1, p.9-15 (2017)
      5. 阿部洋、阿部奈保子
        「環状RNAの合成とその翻訳反応 – 大腸菌と動物細胞の翻訳系」
        実験医学 Vol. 34, No. 13, p. 2201-2207, 羊土社 (2016)
      6. 阿部洋、「有機溶媒に溶ける核酸―DNA触媒の新たな可能性」、現代化学 2013 1月号
      7. 古川和寛、阿部洋、伊藤嘉浩、常田聡
        「生細胞内RNA検出のための化学反応プローブ」「難培養微生物研究の最新技術II~ゲノム解析を中心とした最前線と将来展望~」大熊盛也
        工藤俊章監修、シーエムシー出版、p.19-27 (2010)
      8. 阿部洋
        終わりのない核酸の話
        ケミカルバイオロジー入門
        オーム社
      9. 阿部洋、古沢和寛、常田聡、伊藤嘉浩
        細胞内RNA可視化のためのバイオプローブ
        蛋白質 核酸 酵素
        共立出版株式会社 第52巻 第13号 p1619 (2007)
      10. 和田章、阿部洋、伊藤嘉浩
        アプタマー医薬
        「抗体医薬の最前線」
        シーエムーシー出版 p213 (2007)
      11. 阿部洋、古川和寛、常田聡、伊藤嘉浩
        細胞内遺伝子発現検出用の蛍光バイオプローブの設計と合成
        「一細胞内定量解析の最前線」
        シーエムーシー出版 p135 (2007)
      12. 阿部洋、伊藤嘉浩
        バイオプローブを用いたイメージング法とチップ解析法
        「ナノオプティクス・ナノフォトニクスのすべて」
        フロンティア出版 p157 (2006).

Reviews

      1. Fumiaki Tomoike, Hiroshi Abe
        “RNA imaging by chemical probes”
        Advanced Drug Delivery reviews, 2019, in press
      2. Hiroshi Abe, Yasuaki Kimura
        “Chemical Ligation Reactions of Oligonucleotides for Biological and Medicinal Applications”
        Chemical and Pharmaceutical Bulletin, 2018, 66, 117.
      3. Yuko,Nakashima, Naoko Abe, Yoshihiro Ito, Hiroshi Abe (2014) Nanostructured RNAs for RNA interference. In: Sioud M (ed) RNA interference: challenges and therapeutic opportunities. Methods in molecular biology. Humana Press, New York.
      4. 柴田綾,鵜澤尊規,伊藤嘉浩,周東智,阿部洋, 「非酵素的に高効率シグナル増幅を可能とする新規RNA検出法を開発」、化学と生物、52(11)、771-776 (2014)
      5. 伊藤美香、周東智、伊藤嘉浩、阿部洋
        グルタチオントランスフェラーゼを標的とした分子プローブの開発
        有機合成化学協会誌、70, 822 (2014).
      6. Seiichi Tada, Hiroshi Abe, and Yoshihiro Ito, “PEGylated Antibodies and DNA in Organic Media and Genetic PEGylation” in “Green Polymer 2.” ed. by H. N. Chen and R. A. Gross, ACS, p. 223-233 (2013).
      7. 阿部洋、阿部奈保子、柴田綾、伊藤嘉浩, 「ナノ構造を制御したRNAを用いたRNA干渉法」、アンチセンスDNA/RNA研究会誌 page 3, Vol.16, No.2, November 2012
      8. 阿部洋、柴田綾、古川和寛、常田聡、伊藤嘉浩、「還元反応を引き金とするoff/on型蛍光プローブを用いたRNA検出法の開発」、化学と生物50巻7月号、540p、2012年7月
      9. 劉明哲、阿部洋、伊藤嘉浩
        「進化分子工学による高分子触媒合成と生体高分子のハイブリッド化」
        高分子論文集、68(7), 405-416(2011)
      10. Mingzhe Liu, Hiroshi Abe, Yoshihiro Ito
        Hemin-Binding Aptamers and Aptazymes
        ACS Symposium Series 1043(Green Polymer Chemistry), 111-123 (2010).
      11. 伊藤嘉浩、北嶋隆、阿部洋
        細胞機能制御高分子と再生医療
        高分子 58巻、3月号 2009年3月
      12. 阿部洋,古川和寛,常田聡,伊藤嘉浩,
        細胞内遺伝子シグナルの解析
        生物工学,日本生物工学会,86(6), 268-270, (2008)
      13. Yoshihiro Ito, Hiroshi Abe, Akira Wada, Mingzhe Liu
        Design and synthesis of biorelated polymers by combinatorial bioengineering.
        ACS Symposium Series 999(Polymer Biocatalysis and Biomaterials II), 194-215 (2008),.
      14. 阿部洋、阿部奈保子、原田充、常田聡、伊藤嘉浩
        ダンベル型ナノサークルRNAでRNA干渉を長期安定に
        バイオサイエンスとインダストリー
        バイオインダストリー協会 第66巻 No.8 (2008)
      15. 阿部洋、和田章、伊藤嘉浩
        新機能性核酸・タンパク質を生み出すコンビナトリアル・バイオエンジニアリング
        生物工学会誌 第84巻 第8号 p309 (2006).

Proceedings

      1. Aya Shibata, Hiroshi Abe, Kazuhiro Furukawa, Satoshi Tsuneda, Yoshihiro Ito
        rotein detection using oligonucleotide probes.
        Nucleic Acids Symposium Series, 53, 157-158 (2009).
      2. Hiroshi Abe, Naoko Abe, Miwako Uda, Satoshi Tsuneda, Yoshihiro Ito.
        Synthetic nanocircular RNA for controlling of gene expression
        Nucleic Acids Symposium Series, 53, 65-66 (2009).
      3. Mingze Liu, Takuma Kagahara, Hiroshi Abe, Yoshihiro Ito.
        In vitro selection of RNA aptamer to hemin.
        Nucleic Acids Symposium Series,, 52, 513-514 (2008).
      4. Hiroshi Abe, Naoko Abe, Mitsuru Harada, Satoshi Tsuneda, Yoshihiro Ito.
        Nanocircular RNAs for RNA interference.
        Nucleic Acids Symposium Series, 52, 505-506 (2008).
      5. Kazuhiro Furukawa, Hiroshi Abe, Jin Wang, Kazuma Oki, Miwako Uda, Satoshi Tsuneda, Yoshihiro Ito.
        Fluorogenic probe triggered by reduction for nucleic acids sensing.
        Nucleic Acids Symposium Series,, 52, 353-354 (2008).
      6. Yuko Kondo, Hiroshi Abe, Hiroshi Jinmei, Naoko Abe, Kyoko Aikawa, Isamu Matsumoto, Yoshihiro Ito.
        Multiple chemical ligation under thermal cycle.
        Nucleic Acids Symposium Series,, 51, 365-366 (2007).
      7. Mingze Liu, Hiroshi Jinmei, Koji Fukuzono, Hiroshi Abe, Yoshihiro Ito.
        Intermolecular transfer of aminoacylated adenosine towards chemical aminoacylation of tRNA.
        Nucleic Acids Symposium Series,, 51, 353-354 (2007).
      8. Hiroshi Abe, Naoko Abe, Yoshihiro Ito.
        Structure analysis of oligonucleotide in organic solvent.
        Nucleic Acids Symposium Series,, 50, 25-26 (2006).
      9. Hiroshi Abe, Eric T. Kool.
        Universal linkers for signal amplification in auto-ligating probes.
        Nucleic Acids Symposium Series,, 49, 37-38 (2005).
      10. Satoshi Shuto, Tetsuya Mochizuki, Hiroshi Abe, Yoshihiko Kondo, Akira Matsuda.
        Synthesis and biological activity of adenophostin derivatives as IP3 receptor ligands.
        Nucleic Acids Symposium Series,, 2, 23-24 (2002).

Patents

      • 発明の名称:蛍光発生分子
        発明者:阿部洋、伊藤嘉浩、古川和寛
        出願人:理化学研究所
        国際出願番号:PCT/ JP2008/063871
        登録番号:特許5419278, US 8084201, EP 2204371,
      • 発明の名称:1本鎖環状RNAおよびその製造方法
        発明者:阿部洋、伊藤嘉浩、阿部奈保子、豊福秀一
        出願人:理化学研究所、大塚製薬株式会社
        国際出願番号:PCT/JP2008/058990
        出願国:日本、米国、欧州、他
        登録番号:特許5296328、EP2143792、他59か国
      • 発明の名称:チオールの検出方法、
        発明者:阿部洋、伊藤嘉浩、柴田綾、伊藤美香
        出願人:理化学研究所
        国際出願番号:PCT/JP2009/51579
        登録番号:US 8187825,
      • 発明の名称:核酸の検出方法
        発明者:阿部洋、伊藤嘉浩、古川和寛、氏内圭一、曽家義博
        出願人:理化学研究所、東洋紡績株式会社
        出願番号:特願2007-104938
      • 発明の名称:蛍光発生分子
        発明者:阿部洋、伊藤嘉浩、王瑾、古川和寛
        出願人:理化学研究所
        国際出願番号:PCT/ JP2007/074424
        登録番号:特許5360647, US 8426127
      • 発明の名称:標的核酸配列に基づく目的分子の放出方法
        発明者:阿部洋、伊藤嘉浩、柴田綾、小玉博明
        出願人:理化学研究所
        出願番号:特願2007-289694
      • 発明の名称:環状1本鎖核酸複合体およびその製造方法
        発明者:阿部洋、伊藤嘉浩、阿部奈保子、原田充
        出願人:理化学研究所
        国際出願番号:PCT/JP2009/052945
        出願国:日本、米国、欧州
        登録番号:特許5540312
      • Title: Universal linker compositions for the release or transfer of chemical agents from polynucleotide
        Inventors: Eric T. Kool、Hiroshi Abe
        Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
        Patent No.: US7,745,614
      • 発明の名称: ヌクレオシドまたはヌクレオチド誘導体、核酸誘導体、標的物質捕捉材料、標的物質を捕捉および/または放出する方法、ならびにヘミンアプタマー
        発明者:伊藤嘉浩、劉明哲、阿部洋
        出願人:理化学研究所
        出願番号:特願2008-68842
      • 発明の名称:蛍光発生分子および標的核酸検出方法
        発明者:阿部洋、伊藤嘉浩、柴田綾、伊藤美香
        出願人:理化学研究所
        国際出願番号:PCT/ JP2010/067287
        登録番号:US 8709721
      • 発明の名称:細胞膜透過性ダンベル型RNAおよびその製造方法
        発明者:阿部洋、伊藤嘉浩、阿部奈保子、烏田美和子、中嶋裕子、須賀晶子、高橋政代
        出願人:理化学研究所
        国際出願番号:PCT/JP2011/056492
      • 回転式タンパク質翻訳法
        発明の名称:環状RNA及びタンパク質の製造方法
        発明者:阿部洋、阿部奈保子、伊藤嘉浩、西原みづき
        出願人:理化学研究所
        国際出願番号:PCT/JP2013/053095
        出願国:日本・米国に移行予定
      • 断片化RNAによるビルドアップ法:
        発明の名称:機能性核酸分子の構築法、および当該方法に用いる核酸組合せ物
        発明者:阿部洋、丸山豪斗、伊藤嘉浩
        出願人:独立行政法人科学技術振興機構
        国際出願番号:PCT/JP2013/055732
      • ミニサークル環状RNAからのビルドアップ法
        発明の名称:機能性核酸分子の構築法
        発明者:阿部洋、伊藤美香、伊藤嘉浩
        出願人:理化学研究所
        出願番号:特願2013-012686
      • 発明の名称:新規化合物及び該化合物を含む脂肪滴及び/又は脂肪組織検出用試薬
        発明者:阿部洋、伊藤美香、伊藤嘉浩
        出願人:理化学研究所、東京大学
        国際出願番号:PCT/JP2014/056973
      • 発明の名称:核酸連結法
        発明者:阿部洋、丸山豪斗
        出願人:独立行政法人科学技術振興機構
        出願番号:特願2014-171540

Budgets

    • 科学研究費補助金 基盤B 「ナノ構造化と鋳型反応に基づくRNAの医薬機能創発」(研究代表者)(平成25年~平成27年)
    • 理化学研究所 戦略的研究展開事業「新規翻訳現象の理解と利用」(研究代表者)(平成24年~平成25年)
    • 科学研究費補助金:挑戦的萌芽研究「新規翻訳現象の解析と利用」(研究代表者)(平成24年)
    • 科学技術振興機構 さきがけ 研究領域:「脳神経回路の形成・動作と制御」
      「シナプス可塑性に関わるRNA群の革新的イメージング法の開発」(研究代表者)(平成23年~平成26年)
    • 科学技術振興機構 戦略的国際科学技術協力推進事業 日本-スウェーデン研究交流
      「単一分子レベルの酵素反応解析から癌治療法開発までの複合領域研究」(研究代表者)(平成23年~平成25年)
    • 科学技術振興機構 研究成果最適展開支援プログラム(A-STEP)
      「化学反応プローブとフローサイトメーターを用いた細菌の検出法の検討」(研究代表者)(平成23年~平成24年)
    • 科学研究費補助金:若手研究(A)
      「遺伝子型に基づく細胞分離法」(研究代表者)(平成22年度~平成23年度)
    • 理化学研究所 産業界連携制度交付金
      「化学反応遺伝子検出プローブを用いたPOCウイルス検査法の開発」(研究代表者)(平成22年度~平成23年度)
    • 保健医療分野における基礎研究推進事業
      「ダンベル型RNAを用いる新規RNA医薬品化技術の開発」(研究代表者)(平成21年度~平成23年度)
    • 産業技術研究助成事業 NEDO
      「化学反応プローブよる生細胞内遺伝子発現の検出」(研究代表者)(平成18年度~平成22年度)
    • 理化学研究所 戦略的研究展開事業
      「RNA環状ナノ構造体を用いるRNA干渉法」(研究代表者)(平成20年度~平成22年度)
    • 科学研究費補助金:若手研究(B)
      「化学反応プローブによる遺伝子シグナルの増幅」(20750146)(研究代表者)(平成20年度〜平成21年度)
    • 理化学研究所 奨励研究費
      「有機溶媒中の核酸の構造と機能に関する研究」(研究代表者)(平成18年度)
    • 理化学研究所 奨励研究費
      「有機溶媒に溶ける核酸を用いる分子触媒の創製」(研究代表者)(平成19年度)
    • 科学研究費補助金:若手研究(B)
      「細胞内蛋白質を可視化できるバイオプローブの開発」(18750159)(研究代表者)(平成18年度〜平成19年度)
    • 科学研究費補助金:基盤研究(A)
      「金属・無機材料に結合できる成長因子の創成と医学応用」(研究分担者)(平成19年度〜平成21年度)
    • 科学研究費補助金:萌芽研究
      「有機溶媒中での試験管内進化法による触媒探索」(研究分担者)(平成19年度〜平成20年度)